UCP-2 and UCP-3 Proteins Are Differentially Regulated in Pancreatic Beta-Cells
نویسندگان
چکیده
منابع مشابه
UCP-2 and UCP-3 Proteins Are Differentially Regulated in Pancreatic Beta-Cells
BACKGROUND Increased uncoupling protein-2 (UCP-2) expression has been associated with impaired insulin secretion, whereas UCP-3 protein levels are decreased in the skeleton muscle of type-2 diabetic subjects. In the present studies we hypothesize an opposing effect of glucose on the regulation of UCP-2 and UCP-3 in pancreatic islets. METHODOLOGY Dominant negative UCP-2 and wild type UCP-3 ade...
متن کاملRegulation of skeletal muscle UCP-2 and UCP-3 gene expression by exercise and denervation.
The factors that regulate gene expression of uncoupling proteins 2 and 3 (UCP-2 and UCP-3) in skeletal muscle are poorly understood, but both genes are clearly responsive to the metabolic state of the organism. Therefore, we tested the hypothesis that denervation and acute and/or chronic exercise (factors that profoundly affect metabolism) would alter UCP-2 and UCP-3 gene expression. For the de...
متن کاملT3 stimulates resting metabolism and UCP-2 and UCP-3 mRNA but not nonphosphorylating mitochondrial respiration in mice.
The molecular basis for variations in resting metabolic rate (RMR) within a species is unknown. One possibility is that variations in RMR occur because of variations in uncoupling protein 2 (UCP-2) and uncoupling protein 3 (UCP-3) expression, resulting in mitochondrial proton leak differences. We tested the hypothesis that UCP-2 and -3 mRNAs positively correlate with RMR and proton leak. We tre...
متن کامل2 Weak Ucp and Perturbed Monopole Equations
We give a simple proof of weak Unique Continuation Property for perturbed Dirac operators, using the Carleman inequality. We apply the result to a class of perturbations of the Seiberg–Witten monopole equations that arise in Floer theory.
متن کاملLife without UCP I : mitochondrial , cellular and organismal characteristics of the UCP I - ablated mice
Mice devoid of the original uncoupling protein UCPl have provided opportunities to delineate UCPl function in a series of biochemical and physiological contexts. The isolated brown-fat mitochondria from such mice are fully coupled (without the addition of GDP), but still exhibit a depressed capacity for ATP synthesis. However, they only show a 2-fold decrease in sensitivity to the de-energizing...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS ONE
سال: 2008
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0001397